This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Insulin resistance is an increasingly prevalent cause of cardiovascular morbidity and mortality, and when combined with abnormal insulin release, leads to the development of type 2 diabetes. Reducing insulin resistance is expected to decrease the prevalence of these common disorders. This protocal outlines a program to reduce insulin resistance through sustainable diet and exercise that is inexpensive and readily applicable to individuals at risk in a variety of clinical settings. This is a 6-month trial of diet and exercise therapy in a group of overweight or obese individuals who have at least one additional risk factor for development of diabetes mellitus. Subjects will serve as their own controls and will be examined at baseline and after six months of treatment. The major focus of the study is the ability of a simple diet and exercise program to decrease insulin resistance. It is expected that long-term outcomes of this intervention will not only decrease the prevalence of type 2 diabetes, but also decrease the prevalence of coronary artery disease, peripheral vascular disease, and carotid stenosis.
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