This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Prior evidence suggests that an increase in glycogen stores, as well as an increase in Free Fatty Acid (FFA) concentration inhibits glucose disposal. Based on this, we reason that a higher caloric intake at a given meal should impact insulin sensitivity in the subsequent several hours, even after the glucose comes back to the pre-meal concentration. An important implication of this towards the treatment of type 1 diabetes is as follows. Patients with type 1 diabetes are commonly taught to take insulin according to the amount of carbohydrate anticipated for a given meal. However, considering the above, the caloric amount consumed at a prior meal might also impact this insulin need. So, if an individual with type 1 diabetes ingested antecedent meals of different caloric content on different days and covered these antecedent meals with the appropriate doses of insulin (based on the intake of the antecendent meals), they would, in theory, have returned to the same glycemic level prior to the subsequent meal. However, their insulin needs for the subsequent meal (per unit intake) may then be different (dependent on antecedent intake). This forms the basis for the hypothesis we will test.
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