This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol is primarily an epidemiological study of type 1 diabetes and its complications with particular emphasis on macrovascular disease. The EDIC is designed as a long-term follow-up of participants in the Diabetes Control and Complications Trial (DCCT). The DCCT, which was completed in 1994, was a well known prospective randomized trial of 1,441 subjects randomized to intense versus conventional glycemic control. The results provided compelling evidence of the benefit of glycemic control towards preventing microvascular and neurological complications. The EDIC now offers an opportunity for continued prospective follow-up of this large group of subjects, thus promising new data on the occurrence, pathogenesis, risk factors and treatments of diabetic complications. The EDIC also takes advantage of prior intention-to-treat analysis based on previous involvement of the study population in the DCCT. In addition, the EDIC facilitates the study of macrovascular disease in type 1 diabetes, an issue that the DCCT could not adequately address over the 5-9 year participation of the relatively young subjects (13-39 years old at enrollment in the DCCT). The EDIC also incorporates a genetic component involving family members of participants in order to learn more about the contribution of genes to the development and progression of the long-term complications of type 1 diabetes.
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