Abstract

Barrett's esophagus is a condition in which normal tissue in the lower esophagus is replaced by an abnormal, glandular tissue, which has a potential to undergo malignant transformation to cancer of the esophagus. Surveillance for malignant change is recommended, using regular upper gastrointestinal endoscopy. When malignant change becomes imminent, surgical resection is recommended. Recent evidence suggests that surgery might not always be necessary, as local ablative treatments may be sufficient. Photodynamic therapy sensitizes targeted tissues to light-activated chemistry, which has the potential to kill cells. Preliminary data suggest that premalignant changes of Barrett's esophagus may not progress to invasive cancer when treated with photodynamic therapy. This category D study randomizes patients with premalignant Barrett's esophagus to photodynamic therapy with regular surveillance, or to the more conventional treatment with medications designed to suppress acid formation in the stomach (omeprazole), with surveillance every three months. The surveillance includes upper gastrointestinal endoscopy and biopsy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000064-36
Application #
6406954
Study Section
General Clinical Research Centers Committee (CLR)
Project Start
1977-12-01
Project End
2001-02-28
Budget Start
Budget End
Support Year
36
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
University of Utah
Department
Type
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

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Archer, Stephanie Wilson; Carlo, Waldemar A; Truog, William E et al. (2016) Improving publication rates in a collaborative clinical trials research network. Semin Perinatol 40:410-417
Phelps, Dale L; Ward, Robert M; Williams, Rick L et al. (2016) Safety and pharmacokinetics of multiple dose myo-inositol in preterm infants. Pediatr Res 80:209-17
Harper, Lorie M; Mele, Lisa; Landon, Mark B et al. (2016) Carpenter-Coustan Compared With National Diabetes Data Group Criteria for Diagnosing Gestational Diabetes. Obstet Gynecol 127:893-8
Bowles, Neil E; Jou, Chuanchau J; Arrington, Cammon B et al. (2015) Exome analysis of a family with Wolff-Parkinson-White syndrome identifies a novel disease locus. Am J Med Genet A 167A:2975-84
Priester, Tiffany; Ault, Travis G; Davidson, Lance et al. (2015) Coronary calcium scores 6 years after bariatric surgery. Obes Surg 25:90-6
Adams, T D; Hammoud, A O; Davidson, L E et al. (2015) Maternal and neonatal outcomes for pregnancies before and after gastric bypass surgery. Int J Obes (Lond) 39:686-94

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