This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It is proposed that an increase in bone turnover may play a role in bone pain and development of sickle cell crisis. Therefore this protocol will measure bone metabolism via quantification of serum bone specific alkaline phosphatase and N-telopeptide.
The aim i s to investigate whether increased bone turnover is temporally related to sickle cell crisis.
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