This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to investigate the clinical importance of celiac disease autoimmunity in children without symptoms of celiac disease.
The specific aims of this study are to prospectively compare diabetic children with untreated celiac autoimmunity (TG+) on a gluten-containing diet, to TG- diabetic children (negative control group), and to diabetic children with treated celiac autoimmunity (TG+GFD+[gluten-free diet]) (treatment or positive control group) in terms of: (Assessments will be performed at baseline and over 12 months). 1. Growth velocity 2. Bone mineralization (lumbar spine bone density) 3. Intestinal permeability (lactulose-mannitol ratio) 4. Gut function (13C-sucrose breath test).
Showing the most recent 10 out of 837 publications