This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Emergence agitation (EA), also termed emergence delirium or post anesthetic excitement, is commonly seen in children in the immediate post-operative period. The incidence of this phenomenon is quite variable, ranging from 10-80% in the literature. Several factors have been related to an increased risk for EA including age, type of surgery, type of anesthetic and levels pre-operative anxiety in children and their parents. While an abundance of investigations have looked at the incidence and risk factors of EA, research into its etiology is lacking. Within adult populations, post-operative cognitive deficits have been linked to duration of anesthesia and increased mortality has been correlated with cumulative deep hypnotic time. Our study proposes to investigate the relationship between depth of anesthesia as measured by Bispectral Index (BIS) monitoring, and whether this correlates with the incidence of EA and negative post-operative behavioral changes in children.
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