Abstract

Epidural administration of morphine is a common clinical practice to provide satisfactory analgesia for acute postoperative pain. Scientific evidence results from numerous studies conducted in a clincial pain setting. However, these conditions do not allow investigators to address many questions concerning the pharmacodynamics of epidural morphine. The goal for the current study is to employ a recently developed experimental pain model to study the spread and the time course of analgesia mediated by epidural morphine. To our knowledge this is the first randomized, placebo controlled, double-blind, cross- over study investigating the pharmacodynamics of epidural morphine for a 24 hour period post injection. Thirteen out of 14 healthy subjects have entered the study so far. Analysis of the available data suggests that the onset of analgesia after epidural morphine is very slow, peak effect occurs not before five hours and the drug acts for at least 24 hours. Additionally there is reasonable evidence to suggest that epidural morphine acts mainly by diffusion to the spinal cord as opposed to a systemic re-uptake. Suggested experimental pain model is a suitable pharmacodynamic tool to depict analgesia mediated by epidural morphine.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
3M01RR000070-36
Application #
6276285
Study Section
Project Start
1997-12-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
36
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Type
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

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Frayling, Timothy M; Beaumont, Robin N; Jones, Samuel E et al. (2018) A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure. Cell Rep 23:327-336
Latva-Rasku, Aino; Honka, Miikka-Juhani; Stan?áková, Alena et al. (2018) A Partial Loss-of-Function Variant in AKT2 Is Associated With Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin-Sensitive Tissues: A Genotype-Based Callback Positron Emission Tomography Study. Diabetes 67:334-342
Srinivasan, Lakshmi; Page, Grier; Kirpalani, Haresh et al. (2017) Genome-wide association study of sepsis in extremely premature infants. Arch Dis Child Fetal Neonatal Ed 102:F439-F445
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Denson, Lee A; McDonald, Scott A; Das, Abhik et al. (2017) Early Elevation in Interleukin-6 is Associated with Reduced Growth in Extremely Low Birth Weight Infants. Am J Perinatol 34:240-247
Holmes, Michael V; Pulit, Sara L; Lindgren, Cecilia M (2017) Genetic and epigenetic studies of adiposity and cardiometabolic disease. Genome Med 9:82
Younge, Noelle; Goldstein, Ricki F; Bann, Carla M et al. (2017) Survival and Neurodevelopmental Outcomes among Periviable Infants. N Engl J Med 376:617-628

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