This study is an open-label, multiple dose, dose-escalation protocol to evaluate the safety and preliminary efficacy of an orally administered drug, DMP777, which reduces the inflammation in the lungs caused by excessive activity of white blood cells called neutrophils. The excessive inflammatory activity is due to a chemical called elastase; DMP777 blocks this activity, and is thus an anti-inflammatory drug. In this protocol, patients with cystic fibrosis are evaluated for the presence of the drug in lung fluids by obtaining samples of lung fluids using a technique called bronchoalveolar lavage, these fluids are also assessed for levels of inflammatory cells and chemicals at baseline and after receiving the drug. The body's handling of metabolism of DMP777 is assessed by measures of lung and blood levels after multiple doses.

Project Start
1999-12-01
Project End
2000-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
38
Fiscal Year
2000
Total Cost
$602
Indirect Cost
Name
Stanford University
Department
Type
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
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