This trial is designed to test the safety and immunogenicity of custom-made B-cell lymphoma idiotype protein vaccines made by recombinant DNA techniques. The DNA sequences of each individual B-cell lymphoma patient's tumor-specific immunoglobulin (Ig) variable regions (idiotype)are cloned by PCR and placed into a eukaryotic expression vector. The protein is purified from vector cultures and conjugated to the carrie protein KLH. Eligible patients have follicular B-cell lymphoma in remission following initial chemotherapy. Patients receive five injections of the conjugate along with locally-injected GM-CSF as an adjuvant. Endpoints are antibody and cellular immune responses to the idiotype and KLH, and toxicity.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000070-38
Application #
6408816
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1978-12-01
Project End
2001-11-30
Budget Start
Budget End
Support Year
38
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Stanford University
Department
Type
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
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