Abstract

The GCRC is the major clinical research facility for Stanford University School of Medicine. This proposal involves a total of 99 protocols, 39 principal investigators, and 50 co- investigators from 12 departments. Our goals are to provide an optimal facility for the conduct of patient oriented research, to translate basic scientific knowledge into a better understanding and treatment of human diseases, and to train health professionals in clinical research. Current space in Stanford University Hospital provides an outstanding inpatient and outpatient GCRC facility, and a premature infant research program utilizes scatter beds in the adjacent Lucile Packard Children's Hospital. The eight major programs and investigators which form the core of this proposal are: (1) Recombinant Idiotype Vaccines for the Immunotherapy of Follicular Non- Hodgkin's Lymphomas (RonaldLevy). (2) Clinical Trials in HIV Positive Patients (Thomas C. Merigan). (3) Surgery for Necrotizing Enterocolitis in Human Infants: a Randomized Trial (Lawrence Moss). (4) Studies of Hypothalamic-Pituitary-Adrenal Axis in Psychotic Depression (Alan Schatzberg). (5) A Phase I Study of ZD1839 (Iressa) in Combination with Oxaliplatin, 5-Huorouracil, and Leucovorin in Advanced Solid Malignancies (Branimir I.Sikic). (6) Clinical Experiment of Helicobacter PyloriTransmission (Julie Parsonnet). (7) Pathophysiology of Hepatorenal Syndrome (Bryan D. Myers). (8) Gene Therapy for Hemophilia (Mark Kay and Bertil Glader).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000070-44
Application #
6998469
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Filart, Rosemarie
Project Start
2001-07-01
Project End
2006-11-30
Budget Start
2005-12-01
Budget End
2006-11-30
Support Year
44
Fiscal Year
2006
Total Cost
$4,298,157
Indirect Cost

  Institution

Name
Stanford University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Latva-Rasku, Aino; Honka, Miikka-Juhani; Stan?áková, Alena et al. (2018) A Partial Loss-of-Function Variant in AKT2 Is Associated With Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin-Sensitive Tissues: A Genotype-Based Callback Positron Emission Tomography Study. Diabetes 67:334-342
Evangelou, Evangelos (see original citation for additional authors) (2018) Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat Genet 50:1412-1425
Doherty, Aiden; Smith-Byrne, Karl; Ferreira, Teresa et al. (2018) GWAS identifies 14 loci for device-measured physical activity and sleep duration. Nat Commun 9:5257
Askie, Lisa M; Darlow, Brian A; Finer, Neil et al. (2018) Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration. JAMA 319:2190-2201
Frayling, Timothy M; Beaumont, Robin N; Jones, Samuel E et al. (2018) A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure. Cell Rep 23:327-336
Srinivasan, Lakshmi; Page, Grier; Kirpalani, Haresh et al. (2017) Genome-wide association study of sepsis in extremely premature infants. Arch Dis Child Fetal Neonatal Ed 102:F439-F445
Di Fiore, Juliann M; Martin, Richard J; Li, Hong et al. (2017) Patterns of Oxygenation, Mortality, and Growth Status in the Surfactant Positive Pressure and Oxygen Trial Cohort. J Pediatr 186:49-56.e1
Denson, Lee A; McDonald, Scott A; Das, Abhik et al. (2017) Early Elevation in Interleukin-6 is Associated with Reduced Growth in Extremely Low Birth Weight Infants. Am J Perinatol 34:240-247
Holmes, Michael V; Pulit, Sara L; Lindgren, Cecilia M (2017) Genetic and epigenetic studies of adiposity and cardiometabolic disease. Genome Med 9:82
Younge, Noelle; Goldstein, Ricki F; Bann, Carla M et al. (2017) Survival and Neurodevelopmental Outcomes among Periviable Infants. N Engl J Med 376:617-628

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