This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.This is a prospective study of preterm infants who are admitted to Lucile Packard Children's Hospital with a birth weight less than 1500 grams. This research project involves studies of visual development in human infants designed to: 1) describe the development of visual mechanisms involved in the recognition of objects and patterns; 2) develop clinically useful tests of visual function that can be applied in non-verbal pediatric patients; and 3) to assess the ability of quantitative brain magnetic resonance imaging (MRI) using diffusion tensor to detect brain lesions that are associated with central visual impairment in premature infants.This is a preliminary study that is being conducted for 1 yr to determine the effectiveness of the visual evoked potentials (VEP) and MRI in predicting visual outcome in preterm infants. This data will be used to support an NIH grant application for a long-term follow-up study.
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