This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Food allergy is becoming a major health problem in the United States, affecting about 2.5% of the population, or 6.5 million Americans. Peanut and tree nut allergies affect about 1.1% of the population and fish and shellfish affect approximately 0.5% - 0.7%. Other foods, such as kiwi and various seeds [e.g. sesame, mustard, poppy, etc.] appear to be an increasing problem. Although milk, eggs and peanuts account for over 80% of food hypersensitivity reactions in children, hypersensitivity reactions to peanuts, tree nuts, seeds and seafood tend to be more severe in nature, sometimes resulting in death, and generally are lifelong. Despite the prevalence of these food hypersensitivities and the number of serious anaphylactic reactions each year, the identification of clinically relevant allergens is incomplete and our understanding of the immunobiology of peanut, tree nut, seed and seafood hypersensitivity is very limited. The overall goal of this project is to characterize food allergens responsible for clinical reactivity to a variety of foods and to isolate DNA encoding these proteins. A bank of food allergen DNA will enable us to take advantage of any of a number of novel strategies under investigation for modulating the allergic response in food allergic patients

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000071-43
Application #
7380522
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2006-04-17
Project End
2007-02-28
Budget Start
2006-04-17
Budget End
2007-02-28
Support Year
43
Fiscal Year
2006
Total Cost
$46,649
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
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