This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Space flight seems to lower an astronaut's ability to fight off infection and makes them weak. NASA scientists are working to make astronauts healthier and safer when they spend a long time in space. Head-down bed rest is a good way to pretend a person is traveling in space without gravity. This study will show how much your body, tilted head down and feet up, is like an astronaut's body.
Specific Aims and Procedures (summary): The reason for the bed rest study is to begin getting information on people so that scientists can make ways for the bad results of space flight on astronaut's health to be better. The scientists hope to make a drug, exercise program or anything that will lower the bad changes that happen to astronauts during space flight and that hurt their normal activities after they return to Earth. Experimental Design (summary): Volunteers will live at the hospital in Galveston for 84-days. They will stay in bed for 60 of those days. Along with bed rest, these studies will have mental and physical tests called the Integrated Testing Regimen (ITR). These tests measure changes in your body and mind before, during and after bed rest. Right now, many of these tests are used on astronauts before and after space flight to watch the changes from long trips into space. Significance (summary): The information collected in this study will help plan future space flights and make a way to keep the immune system healthy
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