This is a pharmacokinetic study in healthy volunteers to evaluate the effects of indomethacin on the gastrointestinal elimination and oral bioavailability of furosemide. A pharmacokinetic/pharmacodynamic drug interaction has already been shown for intravenous furosemide with oral indomethacin, and we expect to find a more pronounced interaction for orally dosed furosemide based on in vitro evidence of competition for secretion by an intestinal transporter. The GCRC will be used to house the subjects during the 12-hour study periods, to provide a core lab for sample processing, and to provide dietary support, as well as support for blood draws, i.v. drug dosing and patient monitoring.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
3M01RR000079-36S1
Application #
6264400
Study Section
Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
36
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
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