Our approach to investigate potential P-glycoprotein-related grapefruit juice-drug interactions, based upon categorization into P-gp substrates and non-P-gp substrates, clearly revealed that grapefruit juice exposure has a considerable, activating impact on the secretory efflux of P-gp substrates. We therefore suspect, and will begin to test in this application, that the activating effect of grapefruit juice on P-glycoprotein partially counteracts the CYP3A-inhibitory effects of grapefruit juice.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000079-37A1
Application #
6407592
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1974-12-01
Project End
2003-11-30
Budget Start
Budget End
Support Year
37
Fiscal Year
2000
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
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