The objectives of this study are: 1) to evaluate the biodistribution of fluticasone propionate in the oral cavity, trachea, bronchial passages and lungs as a function of time after oral inhalation when administered using the Flovent metered dose inhaler (MDI) formulation with the manufacturer's actuator according to package directions. 2) to estimate the rate of absorption from each region. 3) to compare the observed time-dependent distribution achieved in four different spacer groups: aerochamber, inspirese, volumatic, and no spacer at all.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000080-40
Application #
6566892
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2001-12-01
Project End
2002-11-30
Budget Start
Budget End
Support Year
40
Fiscal Year
2002
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
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