Abstract

This proposal is for continuing the inpatient, outpatient and scatterbed activities of the General ClinicalResearch Center for adults and children at Shands Hospital of the J. Hillis Miller Health Center at theUniversity of Florida. The GCRC is organized to enhance communications and collaboration in clinicalinvestigative work among health scientists carrying out studies on the unit. These include faculty andtrainees in medicine, pediatrics, clinical psychology, obstetrics and gynecology, surgery, anesthesiology,pharmacy and nutrition. Research-oriented nursing, biostatistical and dietary staff assist in developingdetailed protocols and assure adherence to them. The Program Director, Associate and Assistant Directorsand the Advisory Committee help young investigators develop clinical research proposals and basicinvestigative skills. Extensive core laboratory support is available to facilitate research involving massspectroscopy and genetics.The GCRC enjoys the continuing strong commitment from the administrative leadership of the HealthScience Center. This is reflected in continuing College of MEdicine support for innovative training programs,administrative, and informatics assistance and site renovation. These improvements have enabled theGCRC to remain the focal point of clinical investigation at the University of Florida.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000082-46
Application #
7335651
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Talbot, Bernard
Project Start
1997-02-14
Project End
2011-11-30
Budget Start
2007-12-01
Budget End
2008-11-30
Support Year
46
Fiscal Year
2008
Total Cost
$3,310,387
Indirect Cost

  Institution

Name
University of Florida
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
969663814
City
Gainesville
State
FL
Country
United States
Zip Code
32611

  Publications

Mangal, Naveen; James, Margaret O; Stacpoole, Peter W et al. (2018) Model Informed Dose Optimization of Dichloroacetate for the Treatment of Congenital Lactic Acidosis in Children. J Clin Pharmacol 58:212-220
Boissoneault, Jeff; Letzen, Janelle; Lai, Song et al. (2016) Abnormal resting state functional connectivity in patients with chronic fatigue syndrome: an arterial spin-labeling fMRI study. Magn Reson Imaging 34:603-8
Shumyak, Stepan; Yang, Li-Jun; Han, Shuhong et al. (2016) ""Lupoid hepatitis"" in SLE patients and mice with experimental lupus. Clin Immunol 172:65-71
Hendeles, Leslie; Khan, Yasmeen R; Shuster, Jonathan J et al. (2015) Omalizumab therapy for asthma patients with poor adherence to inhaled corticosteroid therapy. Ann Allergy Asthma Immunol 114:58-62.e2
Price, Catherine C; Levy, Shellie-Anne; Tanner, Jared et al. (2015) Orthopedic Surgery and Post-Operative Cognitive Decline in Idiopathic Parkinson's Disease: Considerations from a Pilot Study. J Parkinsons Dis 5:893-905
Krueger, Charlene A; Cave, Emily C; Garvan, Cynthia (2015) Fetal response to live and recorded maternal speech. Biol Res Nurs 17:112-20
Jones, Jacob D; Marsiske, Michael; Okun, Michael S et al. (2015) Latent growth-curve analysis reveals that worsening Parkinson's disease quality of life is driven by depression. Neuropsychology 29:603-9
Morishita, Takashi; Foote, Kelly D; Archer, Derek B et al. (2015) Smile without euphoria induced by deep brain stimulation: a case report. Neurocase 21:674-8
Del-Aguila, J L; Cooper-DeHoff, R M; Chapman, A B et al. (2015) Transethnic meta-analysis suggests genetic variation in the HEME pathway influences potassium response in patients treated with hydrochlorothiazide. Pharmacogenomics J 15:153-7
Chapman, Arlene B; Cotsonis, George; Parekh, Vishal et al. (2014) Night blood pressure responses to atenolol and hydrochlorothiazide in black and white patients with essential hypertension. Am J Hypertens 27:546-54

Showing the most recent 10 out of 266 publications