Pet Studies of the 5HT2 Receptor Using 18-Setoperone and Cp 88,059

Rubin, Robert H.

Abstract

This study will establish the time course of 5HT2 receptor occupancy in human volunteers, utilizing 18F-setoperone and PET imaging to define the pharmacokinetics of receptor occupancy in normal human brain. Additionally, it is to delineate the effects of CP-88,059 an antipsychotic drug with affinity both for serotonin 5HT2 and dopamine D2, on the pharmacokinetics of receptor binding by 18F-setoperone.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Center for Research Resources (NCRR)
• Type: General Clinical Research Centers Program (M01)
• Project #: 5M01RR000088-32
• Application #: 3741375
• Support Year: 32
• Fiscal Year: 1995

Institution

• Name: Massachusetts Institute of Technology
• City: Cambridge
• State: MA
• Country: United States
• Zip Code: 02139

Publications

Raboud, Janet M; Diong, Christina; Carr, Andrew et al. (2010) A meta-analysis of six placebo-controlled trials of thiazolidinedione therapy for HIV lipoatrophy. HIV Clin Trials 11:39-50

Must, Aviva; Bandini, Linda G; Tybor, David J et al. (2008) Behavioral risk factors in relation to visceral adipose tissue deposition in adolescent females. Int J Pediatr Obes 3 Suppl 1:28-36

Bandini, L G; Must, A; Naumova, E N et al. (2008) Change in leptin, body composition and other hormones around menarche--a visual representation. Acta Paediatr 97:1454-9

Thadhani, Ravi (2008) Activated vitamin D sterols in kidney disease. Lancet 371:542-4

Must, Aviva; Bandini, Linda G; Tybor, David J et al. (2007) Activity, inactivity, and screen time in relation to weight and fatness over adolescence in girls. Obesity (Silver Spring) 15:1774-81

Thompson, O M; Ballew, C; Resnicow, K et al. (2006) Dietary pattern as a predictor of change in BMI z-score among girls. Int J Obes (Lond) 30:176-82

Spadano, Jennifer L; Bandini, Linda G; Must, Aviva et al. (2005) Longitudinal changes in energy expenditure in girls from late childhood through midadolescence. Am J Clin Nutr 81:1102-9

Anderson, S E; Bandini, L G; Must, A (2005) Child temperament does not predict adolescent body composition in girls. Int J Obes (Lond) 29:47-53

Koutkia, Polyxeni; Canavan, Bridget; Breu, Jeff et al. (2004) Nocturnal ghrelin pulsatility and response to growth hormone secretagogues in healthy men. Am J Physiol Endocrinol Metab 287:E506-12

Schurgin, Sunita; Dolan, Sara; Perlstein, Ari et al. (2004) Effects of testosterone administration on growth hormone pulse dynamics in human immunodeficiency virus-infected women. J Clin Endocrinol Metab 89:3290-7