Use of Body Fat and Protein Stores During Fasting and Refeeding

Young, Vernon R.

Abstract

This study will test the hypothesis that the elderly make greater use of protein as a fuel during fasting by doing a comparison of fuel utilization after a 60 hour fast in old and young subjects, using stable isotope tracer infusions. It will also determine if protein and fat stores are replenished at different rates during refeeding in the young and old.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Center for Research Resources (NCRR)
• Type: General Clinical Research Centers Program (M01)
• Project #: 5M01RR000088-32
• Application #: 3741377
• Support Year: 32
• Fiscal Year: 1995

Institution

• Name: Massachusetts Institute of Technology
• City: Cambridge
• State: MA
• Country: United States
• Zip Code: 02139

Publications

Raboud, Janet M; Diong, Christina; Carr, Andrew et al. (2010) A meta-analysis of six placebo-controlled trials of thiazolidinedione therapy for HIV lipoatrophy. HIV Clin Trials 11:39-50

Must, Aviva; Bandini, Linda G; Tybor, David J et al. (2008) Behavioral risk factors in relation to visceral adipose tissue deposition in adolescent females. Int J Pediatr Obes 3 Suppl 1:28-36

Bandini, L G; Must, A; Naumova, E N et al. (2008) Change in leptin, body composition and other hormones around menarche--a visual representation. Acta Paediatr 97:1454-9

Thadhani, Ravi (2008) Activated vitamin D sterols in kidney disease. Lancet 371:542-4

Must, Aviva; Bandini, Linda G; Tybor, David J et al. (2007) Activity, inactivity, and screen time in relation to weight and fatness over adolescence in girls. Obesity (Silver Spring) 15:1774-81

Thompson, O M; Ballew, C; Resnicow, K et al. (2006) Dietary pattern as a predictor of change in BMI z-score among girls. Int J Obes (Lond) 30:176-82

Spadano, Jennifer L; Bandini, Linda G; Must, Aviva et al. (2005) Longitudinal changes in energy expenditure in girls from late childhood through midadolescence. Am J Clin Nutr 81:1102-9

Anderson, S E; Bandini, L G; Must, A (2005) Child temperament does not predict adolescent body composition in girls. Int J Obes (Lond) 29:47-53

Koutkia, Polyxeni; Canavan, Bridget; Breu, Jeff et al. (2004) Nocturnal ghrelin pulsatility and response to growth hormone secretagogues in healthy men. Am J Physiol Endocrinol Metab 287:E506-12

Schurgin, Sunita; Dolan, Sara; Perlstein, Ari et al. (2004) Effects of testosterone administration on growth hormone pulse dynamics in human immunodeficiency virus-infected women. J Clin Endocrinol Metab 89:3290-7