Abstract

This study will provide information concerning the metabolic fate of leucine ingested either as free amino acid in an amino acid mixture or in a protein bound form as intrinsiclly labeled casein. This will be done under conditions of a generous and a semi-limiting leucine intake. Additionally, by administering (2H2)-phenylalanine orally and (2H5)-phenylalanine intravenously this will enable us to compare the effects of feeding amino acids or protein together with the tracer under generous and semi-limiting protein or amino acid supply. Also, the comparison among the two routes of tracer administration will give us quantitative information about the splanchnic extraction of leucine and phenylalanine during different dietary conditions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000088-36
Application #
6115562
Study Section
Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
36
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Type
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

Raboud, Janet M; Diong, Christina; Carr, Andrew et al. (2010) A meta-analysis of six placebo-controlled trials of thiazolidinedione therapy for HIV lipoatrophy. HIV Clin Trials 11:39-50
Must, Aviva; Bandini, Linda G; Tybor, David J et al. (2008) Behavioral risk factors in relation to visceral adipose tissue deposition in adolescent females. Int J Pediatr Obes 3 Suppl 1:28-36
Bandini, L G; Must, A; Naumova, E N et al. (2008) Change in leptin, body composition and other hormones around menarche--a visual representation. Acta Paediatr 97:1454-9
Thadhani, Ravi (2008) Activated vitamin D sterols in kidney disease. Lancet 371:542-4
Must, Aviva; Bandini, Linda G; Tybor, David J et al. (2007) Activity, inactivity, and screen time in relation to weight and fatness over adolescence in girls. Obesity (Silver Spring) 15:1774-81
Thompson, O M; Ballew, C; Resnicow, K et al. (2006) Dietary pattern as a predictor of change in BMI z-score among girls. Int J Obes (Lond) 30:176-82
Spadano, Jennifer L; Bandini, Linda G; Must, Aviva et al. (2005) Longitudinal changes in energy expenditure in girls from late childhood through midadolescence. Am J Clin Nutr 81:1102-9
Anderson, S E; Bandini, L G; Must, A (2005) Child temperament does not predict adolescent body composition in girls. Int J Obes (Lond) 29:47-53
Spadano, Jennifer L; Bandini, Linda G; Must, Aviva et al. (2004) Does menarche mark a period of elevated resting metabolic rate? Am J Physiol Endocrinol Metab 286:E456-62
Anderson, S E; Bandini, L G; Dietz, W H et al. (2004) Relationship between temperament, nonresting energy expenditure, body composition, and physical activity in girls. Int J Obes Relat Metab Disord 28:300-6

Showing the most recent 10 out of 144 publications