Pilot: Diazepam on human plasma melatonin &cGMP levels

Zhdanova, Irina V.

Abstract

Endogenous melatonin is one of the natural sleep promoters. It tends to be low in the elderly, especially those suffering from insomnia. Benzodiazepries are the most popular hypnotic drugs used by the elderly. We plan to test whether a benzodiasepine diazepan alters nocturnal melatonin levels and cGMP concentrations in plasma of people over 50 years old.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Center for Research Resources (NCRR)
• Type: General Clinical Research Centers Program (M01)
• Project #: 5M01RR000088-37
• Application #: 6406007
• Study Section: General Clinical Research Centers Committee (CLR)
• Project Start: 1975-10-01
• Project End: 2000-11-30
• Support Year: 37
• Fiscal Year: 2000

Institution

• Name: Massachusetts Institute of Technology
• City: Cambridge
• State: MA
• Country: United States
• Zip Code: 02139

Publications

Raboud, Janet M; Diong, Christina; Carr, Andrew et al. (2010) A meta-analysis of six placebo-controlled trials of thiazolidinedione therapy for HIV lipoatrophy. HIV Clin Trials 11:39-50

Must, Aviva; Bandini, Linda G; Tybor, David J et al. (2008) Behavioral risk factors in relation to visceral adipose tissue deposition in adolescent females. Int J Pediatr Obes 3 Suppl 1:28-36

Bandini, L G; Must, A; Naumova, E N et al. (2008) Change in leptin, body composition and other hormones around menarche--a visual representation. Acta Paediatr 97:1454-9

Thadhani, Ravi (2008) Activated vitamin D sterols in kidney disease. Lancet 371:542-4

Must, Aviva; Bandini, Linda G; Tybor, David J et al. (2007) Activity, inactivity, and screen time in relation to weight and fatness over adolescence in girls. Obesity (Silver Spring) 15:1774-81

Thompson, O M; Ballew, C; Resnicow, K et al. (2006) Dietary pattern as a predictor of change in BMI z-score among girls. Int J Obes (Lond) 30:176-82

Spadano, Jennifer L; Bandini, Linda G; Must, Aviva et al. (2005) Longitudinal changes in energy expenditure in girls from late childhood through midadolescence. Am J Clin Nutr 81:1102-9

Anderson, S E; Bandini, L G; Must, A (2005) Child temperament does not predict adolescent body composition in girls. Int J Obes (Lond) 29:47-53

Spadano, Jennifer L; Bandini, Linda G; Must, Aviva et al. (2004) Does menarche mark a period of elevated resting metabolic rate? Am J Physiol Endocrinol Metab 286:E456-62

Anderson, S E; Bandini, L G; Dietz, W H et al. (2004) Relationship between temperament, nonresting energy expenditure, body composition, and physical activity in girls. Int J Obes Relat Metab Disord 28:300-6