To determine the maximum tolerated doses of paclitaxel given as a 96 hour infusion in combination with cisplatin in patients with advanced head and neck cancer. To document the type, frequency, and severity of toxicities associated with combination chemotherapy using prolonged infusion paclitaxel and cisplatin. To study the clinical pharmacology of paclitaxel when administered on this schedule and seek pharmacokinetic correlates with clinical endpoints.

Project Start
1997-01-27
Project End
1997-11-30
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
37
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
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