Early rate of HIV-1 RNA decline in CSF is proportional to the decline in plasma in response to transient administration of single-drug therapy w/either nelfinavir or abacavir.
SPECIFIC AIMS : 1) To determine whether initiation of nelfinavir in antiretroviral naive adults is associated w/rapid HIV-1 RNA declines in both plasma and CSF during the first 4 days of therapy. 2) To determine whether initiation of abacavir in antiretroviral naive adults is associated w/rapid HIV-1 RNA declines in both plasma and CSF during the first 4 days of therapy. 3) To determine whether there are differences in CSF HIV-1 RNA decay in response to abacavir vs. nelfinavir, controlling for rates of plasma HIV-1RNA decay. 4)To assess interpatient variability in early virologic response to abacavir and nelfinavir in CSF as compared to plasma.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000095-41
Application #
6424017
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2000-12-01
Project End
2001-11-30
Budget Start
Budget End
Support Year
41
Fiscal Year
2001
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37203
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