This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator.
The specific aim of this proposal is: To test the hypothesis that the ability of low-dose aspirin to suppress thromboxane biosynthesis is impaired in patients with lupus and that this effect is mediated by increased COX-2 activity.
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