This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a pilot study of administration of aerosol Interferon-gamma (IFN-g), an antifibrotic cytokine, to patients with idiopathic pulmonary fibrosis (IPF). A recent, small, Phase I study of subcutaneous IFN-g has shown promising results in patients with IPF. The study will enroll 10 patients with IPF who have failed conventional therapy into a trial which will administer aerosol IFN-g three times per week for 12 weeks. The main objective is to evaluate the efficacy of aerosol delivery of IFN-g to patients with IPF, which will be evaluated by a deposition study. In addition, each patient will undergo pre- and post-treatment bronchoalveolar lavage which will be analyzed for various cytokines and other markers of inflammation. Clinical parameters will be monitored through two dyspnea questionnaires to be filled out pre- and post-treatment.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000096-45
Application #
7378258
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2006-04-01
Project End
2007-03-31
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
45
Fiscal Year
2006
Total Cost
$934
Indirect Cost
Name
New York University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
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