This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Among adults in the United States, asthma has become a major public health problem, with rates most elevated among low-income, urban, African-American and Latino sectors of the population, and with substantial evidence suggesting potential occupational contributions to the excess rates. These important sectors of the U.S. population, however, have been inadequately represented in the occupational asthma research literature. A case-control study of physician-diagnosed asthma, occupation, industry, and workplace environmental exposures is proposed to evaluate the hypothesis that a substantial component of the asthma burden in a low-income, urban, largely-minority population is due to occupational factors. The objective of this study is to evaluate potential occupational contributions to incidence and morbidity of asthma in an urban, low-income, predominantly minority working population with high rates of asthma. This will be accomplished by conducting two linked studies of the patient population of Bellevue Hospital in New York City.
The specific aims are as follows: 1) Conduct a case-control study of new-onset asthma to evaluate the hypothesis that a substantial fraction of incident asthma in the low-income, urban, largely-minority working population served by Bellevue Hospital is attributable to occupational causes. 2) Conduct a prevalence survey to estimate the fraction of prevalent asthma that is aggravated by factors at work, and a second case-control study to evaluate hypotheses of association between aggravation of asthma symptoms at work and specific occupations and workplace exposures.
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