Abstract

Hypothesis: Trymethylpsoralen shower PUVA is an effective therapy in the treatment of psoriasis.
Specific aims : 1. To determine the dose-response relationship of TMP with addition of UVA in producing Mean Phototoxicity Dose (MPD) of aqueous shower delivery of TMP. 2. To ascertain the period of photosensitivity following TMP exposure. 3. To study the efficacy of TMP shower PUVA therapy in the treatment of psoriasis. TMP bath solution has been widely used in Europe but rarely in the United States. This is partially due to the cumbersome administration and disinfecting process required in between bathing each patient. In between treatments, hospital or clinic staff must drain, scrub and sterilize the tub prior to refilling (process takes 30 minutes). This makes this effective treatment not very time- or cost-effective in today's health care settings. We have completed a study of bath PUVA which demonstrated a 90% clinical effectiveness. it follows naturally that a shower can administer the drug in a more cost/time-efficient manner, since a cleaning solution can run through the same plumbing. We wish to determine if """"""""bath"""""""" PUVA can be administered ina practical, cost-effective fashion through use of shower delivery.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000102-36A1
Application #
6409925
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1978-12-01
Project End
2004-11-30
Budget Start
Budget End
Support Year
36
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
Rockefeller University
Department
Type
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

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Butelman, Eduardo Roque; Bacciardi, Silvia; Maremmani, Angelo Giovanni Icro et al. (2017) Can a rapid measure of self-exposure to drugs of abuse provide dimensional information on depression comorbidity? Am J Addict 26:632-639
Ansar, Muhammad; Raza, Syed Irfan; Lee, Kwanghyuk et al. (2015) A homozygous missense variant in type I keratin KRT25 causes autosomal recessive woolly hair. J Med Genet 52:676-80
Rosenbaum, Michael; Leibel, Rudolph L (2014) 20 years of leptin: role of leptin in energy homeostasis in humans. J Endocrinol 223:T83-96
Ohmatsu, Hanako; Humme, Daniel; Gulati, Nicholas et al. (2014) IL32 is progressively expressed in mycosis fungoides independent of helper T-cell 2 and helper T-cell 9 polarization. Cancer Immunol Res 2:890-900
Alemán, José O; Eusebi, Leonardo H; Ricciardiello, Luigi et al. (2014) Mechanisms of obesity-induced gastrointestinal neoplasia. Gastroenterology 146:357-373
Barbuto, Scott; Idoyaga, Juliana; Vila-Perelló, Miquel et al. (2013) Induction of innate and adaptive immunity by delivery of poly dA:dT to dendritic cells. Nat Chem Biol 9:250-6
Guo, Xiuyang; Dhodapkar, Kavita M (2012) Central and overlapping role of Cathepsin B and inflammasome adaptor ASC in antigen presenting function of human dendritic cells. Hum Immunol 73:871-8
Dustin, Lynn B; Charles, Edgar D (2012) Primary, post-primary and non-specific immunoglobulin M responses in HCV infection. Antivir Ther 17:1449-52
Pendyala, Swaroop; Walker, Jeanne M; Holt, Peter R (2012) A high-fat diet is associated with endotoxemia that originates from the gut. Gastroenterology 142:1100-1101.e2

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