This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Nausea and vomiting during pregnancy is a vexing problem for patients and providers. Patients have a strong desire to limit medication use during this period of embryogenesis. Recent evidence has demonstrated the importance of olfaction in the pathogenesis of this disease, with decreased risk of nausea reported in women with anosmia. Volatile oils such as coffee and perfume appear to be especially important triggers. Although it may seem counterintuitive to use a volatile oil in this setting, this olfactory sensitivity may work in reverse as well, with some volatile oils improving rather than triggering symptoms. The proposed study is a double-blind placebo controlled trial of aromatherapy for the treatment of nausea during pregnancy. The relevance of this study is underscored by the common utilization of these therapies despite the lack of controlled trials.
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