This is a multicenter, randomized, double-blind, placebo-controlled clinical trial to determine whether a recombinant human interferon beta product, inter-feron beta-1a (AVONEX), is beneficial in delaying the onset of a new neuro-logical event in subjects who have experienced a first and recent onset of a demyelinating event involving the optic nerve, spinal cord or brainstem and who are at high risk for multiple sclerosis based on the presence of multiple brain magnetic resonance imaging (MRI) signal abnormalities. Recruitment for this study has closed. Three patients remain in the double-blind study. Several patients have received a clinical diagnosis of Multiple Sclerosis and have thus reached the study end point.

Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
36
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Yale University
Department
Type
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
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Arslanian, Silva; El Ghormli, Laure; Bacha, Fida et al. (2017) Adiponectin, Insulin Sensitivity, ?-Cell Function, and Racial/Ethnic Disparity in Treatment Failure Rates in TODAY. Diabetes Care 40:85-93
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