The General Clinical Research Center of the Baylor College of Medicine at Texas Children's Hospital aims to apply basic research knowledge and sophisticated patient-oriented research tools to better understand the pathogenesis, diagnosis, and treatment of pediatric diseases. The GCRC provides for 68 interdisciplinary clinical investigations by 41 principal investigators from 13 sections within the Department of Pediatrics including Allergy/Immunology, Genetics, Neonatology, Hematology/ Oncology, Endocrinology/Metabolism, Infectious Diseases, Critical Care Medicine, Nephrology, Neurology, Gastroenterology, Adolescent Medicine, Rheumatology, and the Children's Nutrition Research Center. To accomplish its goals, the General Clinical Research Center is structured to accommodate patitent-oriented research activities at appropriate sites throughout the Department of Pediatrics under a single administrative structure. Within Texas Children's Hospital, this configuration includes the principal, general purpose inpatient and outpatient unit, a specialized neonatal research satellite unit located within the neonatal intensive care unit, a satellite site for study of critically ill children located within the pediatric intensive care unit, and a gene vector production core laboratory. An additional specialized neonatal research satellite unit is located in the Ben Taub General Hospital in the Texas Medical Center, and a fourth satellite unit to study the nutritional needs of normal infants and children is located in the Children's Nutrition Research Center located adjacent to the Texas Children's Hospital. These facilities will afford investigators an opportunity to carry out multifaceted clinical research projects on pediatric subjects with a weighted emphasis of AIDS, infants born prematurely, molecular/clinical genetics, and gene replacement therapy.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000188-34
Application #
2546543
Study Section
General Clinical Research Centers Committee (CLR)
Project Start
1978-12-01
Project End
2001-11-30
Budget Start
1997-12-01
Budget End
1998-11-30
Support Year
34
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Pediatrics
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
Hunsaker, Sanita L; Garland, Beth H; Rofey, Dana et al. (2018) A Multisite 2-Year Follow Up of Psychopathology Prevalence, Predictors, and Correlates Among Adolescents Who Did or Did Not Undergo Weight Loss Surgery. J Adolesc Health 63:142-150
Lanzieri, Tatiana M; Chung, Winnie; Leung, Jessica et al. (2018) Hearing Trajectory in Children with Congenital Cytomegalovirus Infection. Otolaryngol Head Neck Surg 158:736-744
Bollard, Catherine M; Tripic, Tamara; Cruz, Conrad Russell et al. (2018) Tumor-Specific T-Cells Engineered to Overcome Tumor Immune Evasion Induce Clinical Responses in Patients With Relapsed Hodgkin Lymphoma. J Clin Oncol 36:1128-1139
Michalsky, Marc P; Inge, Thomas H; Jenkins, Todd M et al. (2018) Cardiovascular Risk Factors After Adolescent Bariatric Surgery. Pediatrics 141:
Lau, Chantal (2018) Breastfeeding Challenges and the Preterm Mother-Infant Dyad: A Conceptual Model. Breastfeed Med 13:8-17
Gururangan, Sridharan; Reap, Elizabeth; Schmittling, Robert et al. (2017) Regulatory T cell subsets in patients with medulloblastoma at diagnosis and during standard irradiation and chemotherapy (PBTC N-11). Cancer Immunol Immunother 66:1589-1595
Lanzieri, T M; Leung, J; Caviness, A C et al. (2017) Long-term outcomes of children with symptomatic congenital cytomegalovirus disease. J Perinatol 37:875-880
El-Hattab, Ayman W; Zarante, Ana Maria; Almannai, Mohammed et al. (2017) Therapies for mitochondrial diseases and current clinical trials. Mol Genet Metab 122:1-9
Jin, Haoxing Douglas; Demmler-Harrison, Gail J; Coats, David K et al. (2017) Long-term Visual and Ocular Sequelae in Patients With Congenital Cytomegalovirus Infection. Pediatr Infect Dis J 36:877-882
Oh, Sam S; Du, Randal; Zeiger, Andrew M et al. (2017) Breastfeeding associated with higher lung function in African American youths with asthma. J Asthma 54:856-865

Showing the most recent 10 out of 459 publications