This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose to evaluate the absorption of 5 key minerals in the diets of toddlers and small children one through three yrs of age (12 to 48 months) using stable isotope methods. Calcium, iron, zinc, magnesium and copper absorption will be measured at the 25th to 75th percentile of usual American intakes. These studies will be performed in children of both genders who are selected to match the ethnic distribution of the Greater Houston area. Absorption of calcium, magnesium and zinc will be measured using multi-tracer stable isotope methods with urinary recovery of the administered isotopes. For copper, only one orally administered tracer is available and thus fecal recovery of this tracer will be measured. Iron will be assessed by red blood cell incorporation of administered iron stable isotopes. For zinc and calcium, a subset of studies will be done in which fecal recovery of tracers is performed to assess endogenous fecal mineral excretion. These data will provide previously unavailable information that will be critical in the determination of recommended mineral intake in this vulnerable group of children. Our findings will lead to improved dietary guidelines and the potential for a decrease in conditions related to mineral deficiency in children and adults including anemia and osteoporosis.
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