This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Iron deficiency anemia is common in toddlers of the United States. Weaning foods such as rice cereal have been fortified with iron for decades in an attempt to address and treat this condition. The efficacy of such fortification has been doubted as it is particularly difficult to fortify rice cereal with sources of iron that have high bioavailability. While iron in the form of dried bovine hemoglobin has been found to have higher bioavailability than inorganic iron, issues of acceptability and discoloration have impeded its routine use as a fortificant. Iron protoporphyrin, the iron- containing portion of hemoglobin, can be isolated from animal sources or manufactured chemically. We will examine the absorption of chemically manufactured iron protoporphyrin with the absorption of ferrous sulfate, a non-heme iron source commonly used to fortify weaning foods and frequently prescribed by pediatricians for the treatment of iron deficiency anemia.
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