This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.HYPOTHESISTo identify functional neuroanatomical ocrrelates of parent-infant attachemnt, measuring maternal/paternal functional MRI responses to infant facial cues.HI: Compared with insecure mother-infant dyads, secure-autonomous mothers will demonstrate significantly more fMRI activation of the right orbitofrontal cortex when exposed to their own infant vs. unknown infant facial imates. Other areas of significant difference will include the nucleus accumbens (reward area), amygdala and hippocampus (stress responses) and bed nucleus of the striae terminales (oxytocin pathways).To idently differences in secure vs. insecure mothers' infant-related stress responses, measuring sequential serum oxytocin, cortisol and catecholamines levels.H2: Following the still-face stressor of the Mirror Interaction Situation, ocytocin levels will rise from baseline in secure-autonomous mothers, but remain unchanged or decrease in insecurely attached mothers.H2: Insecure-classified mothers will demonstrate an elevated basal cortisol, and show an exaggerated catecholamine response to the infant-related stressor, compared to secure mothers.To determine differences between attachment groups in other-infant responses using the Mirror Interaction Situation.H3: Insecure-classified mothers will demonstrate fewer contingent facial responses to their infant during the Mirror Interaction Situaiton and CARE-Index.H3: Insecurely attached infants (particularly disorganized infants) will demonstrate a preference for perfectly contingent self-stimulation (i.e. their own image) over their mother's image in the Mirrow Interaction Situation.To determine the degree of correlation between maternal and infant attachment classifications. There will be a significant correlation between secure autonomous maternal attachment classification, using the Adult Attachment Interview, and secure infant classification six months later, using the Strange Situation procedure.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000188-43
Application #
7605883
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2007-02-15
Project End
2007-11-30
Budget Start
2007-02-15
Budget End
2007-11-30
Support Year
43
Fiscal Year
2007
Total Cost
$9,080
Indirect Cost
Name
Baylor College of Medicine
Department
Pediatrics
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Hunsaker, Sanita L; Garland, Beth H; Rofey, Dana et al. (2018) A Multisite 2-Year Follow Up of Psychopathology Prevalence, Predictors, and Correlates Among Adolescents Who Did or Did Not Undergo Weight Loss Surgery. J Adolesc Health 63:142-150
Lanzieri, Tatiana M; Chung, Winnie; Leung, Jessica et al. (2018) Hearing Trajectory in Children with Congenital Cytomegalovirus Infection. Otolaryngol Head Neck Surg 158:736-744
Bollard, Catherine M; Tripic, Tamara; Cruz, Conrad Russell et al. (2018) Tumor-Specific T-Cells Engineered to Overcome Tumor Immune Evasion Induce Clinical Responses in Patients With Relapsed Hodgkin Lymphoma. J Clin Oncol 36:1128-1139
Michalsky, Marc P; Inge, Thomas H; Jenkins, Todd M et al. (2018) Cardiovascular Risk Factors After Adolescent Bariatric Surgery. Pediatrics 141:
Lau, Chantal (2018) Breastfeeding Challenges and the Preterm Mother-Infant Dyad: A Conceptual Model. Breastfeed Med 13:8-17
Gururangan, Sridharan; Reap, Elizabeth; Schmittling, Robert et al. (2017) Regulatory T cell subsets in patients with medulloblastoma at diagnosis and during standard irradiation and chemotherapy (PBTC N-11). Cancer Immunol Immunother 66:1589-1595
Lanzieri, T M; Leung, J; Caviness, A C et al. (2017) Long-term outcomes of children with symptomatic congenital cytomegalovirus disease. J Perinatol 37:875-880
El-Hattab, Ayman W; Zarante, Ana Maria; Almannai, Mohammed et al. (2017) Therapies for mitochondrial diseases and current clinical trials. Mol Genet Metab 122:1-9
Jin, Haoxing Douglas; Demmler-Harrison, Gail J; Coats, David K et al. (2017) Long-term Visual and Ocular Sequelae in Patients With Congenital Cytomegalovirus Infection. Pediatr Infect Dis J 36:877-882
Oh, Sam S; Du, Randal; Zeiger, Andrew M et al. (2017) Breastfeeding associated with higher lung function in African American youths with asthma. J Asthma 54:856-865

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