Abstract

The purpose is to determine whether intranasal administration of DDAVP 2 hours prior to infusion of very high purity (monoclonal antibody purified plasma-derived or recombinant) human FVIII concentrate in 10 patients with severe hemophilia A will prolong plasma half life of the infused FVIII. Prolonging the circulating half life of a FVIII concentrate would facilitate delivery of cost-effective inpatient and outpatient care to patients with hemophilia.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000211-32
Application #
5220164
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
32
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Nyenwe, Ebenezer; Owei, Ibiye; Wan, Jim et al. (2018) Parental History of Type 2 Diabetes Abrogates Ethnic Disparities in Key Glucoregulatory Indices. J Clin Endocrinol Metab 103:514-522
Messier, Stephen P; Resnik, Allison E; Beavers, Daniel P et al. (2018) Intentional Weight Loss in Overweight and Obese Patients With Knee Osteoarthritis: Is More Better? Arthritis Care Res (Hoboken) 70:1569-1575
Sanders, John T; Hastings, M Colleen; Moldoveanu, Zina et al. (2017) Serial Galactose-Deficient IgA1 Levels in Children with IgA Nephropathy and Healthy Controls. Int J Nephrol 2017:8210641
Pogacnik Murillo, Aarón Leonardo; Eckstein, Felix; Wirth, Wolfgang et al. (2017) Impact of Diet and/or Exercise Intervention on Infrapatellar Fat Pad Morphology: Secondary Analysis from the Intensive Diet and Exercise for Arthritis (IDEA) Trial. Cells Tissues Organs 203:258-266
Messier, S P; Beavers, D P; Herman, C et al. (2016) Are unilateral and bilateral knee osteoarthritis patients unique subsets of knee osteoarthritis? A biomechanical perspective. Osteoarthritis Cartilage 24:807-13
Boucher, Andrew B; Adesanya, E A Omoluyi; Owei, Ibiye et al. (2015) Dietary habits and leisure-time physical activity in relation to adiposity, dyslipidemia, and incident dysglycemia in the pathobiology of prediabetes in a biracial cohort study. Metabolism 64:1060-7
Hunter, D J; Beavers, D P; Eckstein, F et al. (2015) The Intensive Diet and Exercise for Arthritis (IDEA) trial: 18-month radiographic and MRI outcomes. Osteoarthritis Cartilage 23:1090-8
Pfeffer, Lawrence M; Li, Kui; Fleckenstein, Jaquelyn F et al. (2014) An interferon response gene signature is associated with the therapeutic response of hepatitis C patients. PLoS One 9:e104202
Look AHEAD Research Group (2014) Effect of a long-term behavioural weight loss intervention on nephropathy in overweight or obese adults with type 2 diabetes: a secondary analysis of the Look AHEAD randomised clinical trial. Lancet Diabetes Endocrinol 2:801-9
Messier, Stephen P; Beavers, Daniel P; Loeser, Richard F et al. (2014) Knee joint loading in knee osteoarthritis: influence of abdominal and thigh fat. Med Sci Sports Exerc 46:1677-83

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