This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a dose escalation study designed to determine whether specific doses of bovine CII will induce immune tolerance in patients with rheumatoid arthritis who will remain on their current treatment plans for DMARD, NSAID and prednis
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