Abstract

This is a study of the effect of Ca channel blockade with nifedipine and diltiazem in normals and patients with essential hypertension. Results show that increased pressor sensitivity of the blood pressure to angiotensinII (A-II) on a high Na diet is largely blocked by nifedipine and diltiazem, while increased aldosterone response to A-II on a low Na diet is partially blocked by both drugs. Similiar studies are planned with ACTH.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000229-25
Application #
3885839
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
25
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Upstate Medical University
Department
Type
DUNS #
058889106
City
Syracuse
State
NY
Country
United States
Zip Code
13210

  Publications

Streeten, D H (1995) Idiopathic edema. Pathogenesis, clinical features, and treatment. Endocrinol Metab Clin North Am 24:531-47
Breslau, N A; Weinstock, R S (1988) Regulation of 1,25 (OH)2D synthesis in hypoparathyroidism and pseudohypoparathyroidism. Am J Physiol 255:E730-6
Haas, D C; Anderson Jr, G H; Streeten, D H (1985) Role of angiotensin in lethal cerebral hypoperfusion during treatment of acute hypertension. Arch Intern Med 145:1922-4