Abstract

This study was designed to determine the pathophysiological abnormality in patients with orthostatic hypertension. Methods will include measurement of arteriolar responsiveness to norepinephrine, determination of alpha-2 adrenergic receptor function by binding of triatiated yohimbine to platelets, and in vitro responsivenesss of segments of excised saphenous veins to norepinephrine.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000229-25
Application #
3885847
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
25
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Upstate Medical University
Department
Type
DUNS #
058889106
City
Syracuse
State
NY
Country
United States
Zip Code
13210

  Publications

Streeten, D H (1995) Idiopathic edema. Pathogenesis, clinical features, and treatment. Endocrinol Metab Clin North Am 24:531-47
Breslau, N A; Weinstock, R S (1988) Regulation of 1,25 (OH)2D synthesis in hypoparathyroidism and pseudohypoparathyroidism. Am J Physiol 255:E730-6
Haas, D C; Anderson Jr, G H; Streeten, D H (1985) Role of angiotensin in lethal cerebral hypoperfusion during treatment of acute hypertension. Arch Intern Med 145:1922-4