This is a phase I study for safety. It is a double-blind, randomized, placebo-controlled study comparing changes in GFR and urinary prostaglandins after administration of SC-58635 or naproxen to patients with stable CRF. Either SC-58635 200 mg. BID, naproxen 500 mg. BID or placebo is given for six consecutive days followed by a single day 7:00 am dose. Safety is assessed by physical exams, clinical labs, weight, blood pressure and pulse, and adverse signs and symptoms.

Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
33
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Type
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239
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