Participants in this research study include patients with end-stage liver disease who are being prepared to undergo liver transplantation, as well as healthy individuals without medical problems who will serve as a comparison group. The purpose of this study is to determine the relationship between the metabolic abnormalities of liver function before and shortly after liver transplantation. This study will evaluate how metabolic function of the liver is deranged as a result of end stage liver disease, how this responds to a lactic acid-lowering drug called dichloroacetate (DCA), and how metabolic function returns to normal after liver transplantation.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000334-34
Application #
6411366
Study Section
Special Emphasis Panel (ZRR1)
Project Start
1976-12-01
Project End
2004-11-30
Budget Start
Budget End
Support Year
34
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Type
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239
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