The objective of this study is to test the hypotheses that: 1) patients with IDDM have circadian changes in insulin sensitivity; 2) these changes are caused by circadian changes in hepatic glucose production and 3) that the circadian changes in hepatic glucose production can be altered with Metformin. The findings are likely to be of considerable clinical importance. Metformin is known to lower blood glucose by suppressing HGP. We hypothesize that it will be able to inhibit circadian nocturnal HGP and improve/facilitate glycemic control.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000349-31A1
Application #
6278198
Study Section
Project Start
1998-09-15
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
31
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Temple University
Department
Type
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19122
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