This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Fatigue is considered one of the most common and most disabling symptoms for persons with multiple sclerosis (MS) and often limits their ability to perform their work, participate in recreation, and complete self-care activities. Over time, the decreased level of activity results in deconditioning, which also exacerbates fatigue. There is preliminary evidence that aerobic exercise has beneficial effects in managing fatigue for persons with MS. The broad, long-term goal objective is to evaluate the effectiveness of various non-pharmacological strategies used to manage fatigue and improve the quality of life for persons with MS.
The specific aim of this pilot study is to determine the efficacy of a home-based aerobic exercise program to remediate deconditioning of persons with MS. It is hypothesized that the aerobic exercise program will improve cardiovascular fitness, improve vascular function, improve functional activity levels, decrease fatigue impact, and improve quality of life.
Showing the most recent 10 out of 724 publications
