This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The planned double-blind crossover placebo controlled study would assess the effect of 1 month of paraoxtine treatment on cardiovascular response and psychological discomfort during 2 mental stress tasks in smokers immediately after smoking a cigarette
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