This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.In adults, ingestion of high carbohydrate drinks has been shown to acutely impair vascular endothelial function, however, this remains to be examined in children. Obese children and adolescents have impaired endothelial function at baseline compared to normal weight controls. We believe that these two groups of children will display different acute vascular responses to a high carbohydrate drink. Therefore, the purpose of this study is to examine the acute vascular endothelial response to an oral glucose load between obese, and normal weight control, children and adolescents. We will address this aim by recruiting 40 children and adolescents (age 10-14) to undergo body composition assessment (via DEXA scan), anthropometric measurments (height, weight, waist to hip ratio), an oral glucose tolerance test (OGTT) with concomitant vascular function measurement via endothelium-dependent flow-mediated vasodilation (FMD) in the GCRC. Subjects will arrive at the GCRC after an overnight fast and be assessed body composition and anthropometry, and baseline vascular function and blood values of glucose, insulin and lipids. Following ingestion of 75 g of liquid glucose, subjects will have blood samples taken (for glucose and insulin) at 30 min intervals for 3 hours. Vascular function will be assessed at 1 hr intervals for 3 hours. The body composition/aanthropometric measurments, baseline blood draw, OFTT, and vascular function measurments will all be conducted through the GCRC. Results will provide insight into the acute vascular effects of high carbohydrate ingestion in healthy and obese children and adolescents.
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