This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The purpose of this supplemental study is to further evaluate subjects who had been vaccinated with a nicotine vaccine (Nic VAX). Following a booster vaccination, subjects will be seen in the GCRC to determine the effects of vaccination on nicotine pharmacokinetics following an i.v. nicotine infusion. Also evaluated are the subjective effects of nicotine. Vaccinated subjects will be compared to controls who have not received the vaccine.
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