This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this project we intend to develop non-invasive methods to quantitatively assess cerebral metabolism during functional activation. The hypothesis of this project is that brain functional activation alters cerebral gluramate turnover. The basis for this assumption is that the measurement of glutamate turnover reflects the rate of the tricarboxylic acid (TCA) cycle and thus the cerebral metabolic rate of oxygen (CMR02). Essential to their performance of these studies will be experimental control and measurement of serum glucose, and insulin concentrations using the techniques employed for glucose clamps.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000400-41
Application #
7951642
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2008-12-01
Project End
2009-11-30
Budget Start
2008-12-01
Budget End
2009-11-30
Support Year
41
Fiscal Year
2009
Total Cost
$4,391
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
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