This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The California NeuroAIDS Tissue Network (CNTN) represents the collaborative efforts of investigators at the NIMH-funded HIV Neurobehavioral Research Center (HNRC) in San Diego and investigators at four collaborating University-affiliated hospitals (LA County Medical Center/University of Southern California (USC), Harbor-UCLA amp; Cedars-Sinai Medical Center, University of California Los Angeles (UCLA), and University of California San Diego (UCSD). The HNRC has already established a local HIV CNS tissue bank as part of a longitudinal neurobehavioral study of HIV-infected persons, demonstrating the feasibility of relating neurobehavioral data to neuropathology at autopsy. The CNTN provides structures and processes for identifying and characterizing persons with advanced HIV disease who are near death; harvesting CNS and other tissues promptly at autopsy; describing, cataloguing, and storing these at a central facility in San Diego; and making samples and data available for investigative work on NeuroAIDS. The goal of the CNTN is to further understanding of the neurological complications of HIV infection In summary, this study will look at the impact of HIV on the brain. Subjects will be followed every 6 months and detailed analysis of brain function will be performed. Subjects will consent to an autopsy in the event that they should die while taking part in this study. A neurological tissue bank will be created as a result of this study which will be able to link clinical neurological symptoms with any irregularities found in the brain after death.
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