This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to look at glucose metabolism (how the body breaks down blood sugar), the amounts of lipids (fats), proteins, and other substances in the blood, the amount of body fat and fat distribution, and how dense (solid) bones are in: a) HIV-infected children compared to HIV-uninfected children; b) HIV-infected children and uninfected children at different stages of sexual development; c) HIV infected children taking a class of anti-HIV drugs called protease inhibitors (PIs) compared to HIV-infected children not taking PIs. About 450 children will take part in this study, 7-14 from the Harbor-UCLA site. The child will have two special x-rays done. These x-rays are called dual energy x-ray absorptiometry (DEXA) scans. One of the x-rays will scan the whole body and the other x-ray will scan just the spine and hip. The child's height and weight will be measured. The distance around the child's waist, hips, arm and thigh will be measured using a measuring tape. Folds of skin will be measured at the child's arm, shoulder, stomach, hip and thigh using calipers, a harmless device that looks like pliers. The child will be asked to answer some questions about changs in his/her body image and appearance. The child will be asked some questions about the kinds of food the child eats normally and how often the child eats. The child will also be asked specific questions about the food the child ate the day before he/she came to the clinic. Routine and special blood tests will be drawn. The study will be from 1 visit (3 hrs) to 3 visits (each 1-2 hrs) within 30 days.
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