Stroke Prevention in Atrial Fibrillation (SPAF 3) is a multicenter, NIH funded trial to determine the best and safest way to reduce stroke risk in atrial fibrillation. Based on data from SPAF2, patients with chronic atrial fibrillation will be stratified according to high or low risk of stroke. Patients at low risk of stroke will be treated with one aspirin per day (325mg) and those at high risk of stroke will be randomized to receive either Warfarin in a standard dose to maintain a INR at 2-3 or low Warfarin (1-3mg sufficient to midly elevate the INR to 1.3). Subjects will be following at regular intervals with baseline and regular neurological examinations to determine any evidence of stroke and to determine any complications of therapy.

Project Start
1997-12-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
30
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Boston University
Department
Type
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
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