This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary goal of this clinical research protocol is to determine, in adults with varying skin types, the quantitative changes in circulating concentrations of vitamin D and its metabolites in response to multiple suberythemal exposures to simulated sunlight. Patients will be exposed to a tanning bed for three months during late fall and winter. It is hypothesized that exposure to tanning bed radiation will increase serum vitamin D and 25(OH)D levels, and reduce serum PTH and urine NTX in subjects who are vitamin D insufficient. The secondary goal of this clinical research protocol is to quantitatively measure from punch biopsies, the expression of genes related to vitamin D metabolism, cell proliferation and differentiation, DNA damage and repair, B-endorphin and circadian rhythm. In addition, we will measure skin pigmentation before and immediately after each irradiation during the study using Datacolor microflash spectrophotometer to quantitate the degree of melanin pigmentation and any erythema that results from exposures to simulated sunlight in a tanning be
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